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KMID : 0603520010060030140
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Journal of Korean Association of Cancer Prevention
2001 Volume.6 No. 3 p.140 ~ p.147
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Reduced Comutagenic and Antimutagenic Effects of Bamboo Salt Prepared with KC1 and NaC1
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Jung Keun-Ok
Lee Sun-Mi
Lee Sook-Hee
Park Kun-Young
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Abstract
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To reduce the effect of salt on mutagenicity, the KC1 mixed (chunil salt : KC1=3~7 : 7~3) bamboo salt (BS) was developed. Comutagenic/antimutagenic effects of KC1 mixed BS were investigated in Ames test, SOS chromotest and micronucleaus test. All the salts studied showed comutagenic effects on the N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium TA100. One time heat treated BS1 X K7 (chunil salt : KC1= 3 : 7) exerted the lowest comutagenic activity among the salts. In SOS chromotest using E. coli PQ37, Guwoon salt (GS), 9 times heat treated BS and the KC1 mixed BS samples blocked the SOS response induced by MNNG, while purified salt (PS) increased the SOS induction factor. One time heat treated BS1 X K7 exhibited the highest antimutagenic activity among the KC1 mixed BS. The induction of chromosome abberations by mitomycin C was increased by pre-treatment with salt. However, GS and 9 times heat treated BS significantly decreased the frequency of micronucleated reticulocytes compared to the PS (p<0.05). One time heat treated BS had more suppressive effects on chromosome abberation than KC1 and the mixture of chunil salt and KC1 (3 : 7). These result indicated that the KC1 mixed BS1 X K7 showed the lowest comutagenic effects among the salts and the ratio of K and Na was important factor to reduce comutagenicity or to increase antimutagenicity of salt in the mutagenicity test system.
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KEYWORD
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KC1, Bamboo salt, Comutagenicity, Antimatagenicity
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